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Prenatal genetic screening to help patients prepare
Prequel is the only prenatal cell-free DNA (cfDNA) screen with revolutionary AMPLIFY technology that increases fetal fraction for everybody, including patients with high BMI.
Why screen with Prequel?
Screen 99.9% of all patients
Prequel® is the only cell-free DNA screen that delivers clear answers to over 99.9% of patients on the first draw at 10 weeks regardless of BMI—for the lowest failure rate in the industry of just 0.1%.1,2,3
Up to 100% PPV for 22q microdeletion detection
Give your patients the confidence of the highest published positive predictive values (PPV) of up to 100% for 22q microdeletion syndrome detection.4
Clear results, next steps, and support
Prequel results deliver clarity of a patient’s true risk with individualized PPV and residual-risk estimates to help inform next steps. All results include on-demand access to our board certified genetic counselors to ensure prenatal screening results are understood.
Clear prenatal screening results to inform patients and clinicians
Every Prequel Prenatal Screen provides clear, user-friendly results and access to board-certified genetic counselors for post-test education and counseling.
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Clear, personalized risk of serious conditions
Prequel reports include results for each chromosome condition screened, including trisomies, sex chromosomes, microdeletions and expanded aneuploidies. Results include screening methodology and a patient-specific risk using the test’s positive predictive value (PPV) for positive test results, or residual risk for negative results.
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Detailed information for detected conditions
Each detected condition includes a detailed summary, including recent and relevant references to help clinicians personalize and guide care.
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Reveal predicted fetal sex
For interested patients, Prequel results can also provide the predicted sex of a baby for singleton or twin pregnancies.
Guide informed planning and preparation
Prequel’s results help clinicians guide care and empower patients to take action to make the best decision for their family.
Explore different options such as:
Consulting with specialists
Knowing if a child requires a certain type of care before birth means you can involve the right kind of specialists long before delivery.
Finding the right place to deliver
Seek out a specialized facility that is equipped to manage newborns with chromosome conditions.
Seeking support
Guide your patients to talk with one of our board-certified genetic counselors or work with a support group to understand what could lie ahead.
Expert patient support at every step
From on-demand patient education to clear results reporting, Myriad offers seamless patient care throughout the entire Prequel screening process.
Prequel patients have unlimited access to one of Myriad’s 50+ board-certified genetic counselors to help understand prenatal screening and their results.
How to test with the Prequel Prenatal Screen
Discuss Prequel screening with your patient and collect a patient blood sample
Discuss Prequel screening with your patient and collect a patient blood sample
Submit patient sample and completed Test Request Form to Myriad, or place an order in the Myriad Provider Portal
Submit patient sample and completed Test Request Form to Myriad, or place an order in the Myriad Provider Portal
Receive results in less than two weeks and review with patient
Receive results in less than two weeks and review with patient
Refer patients to schedule a consultation with Myriad’s board-certified genetic counselors
Refer patients to schedule a consultation with Myriad’s board-certified genetic counselors
What to expect with every screen
Actionable
Every Prequel Prenatal Screen provides actionable results within two weeks to inform patient care decisions.
Affordable
Myriad is committed to providing patients with access to reliable and affordable genetic results through extensive coverage with most insurance plans and financial assistance programs.
Reliable
Myriad believes in providing the highest quality screens for patients. From prenatal screens to precision medicine, our products are designed to give providers and patients the most reliable answer possible
Related screens and tests
Foresight® Carrier Screen detects a couple’s risk of passing down serious, inheritable health conditions to their child to guide informed planning and preparation.
- Identify the 1 in 22 couples at risk for pregnancies with serious, prevalent, or clinically-actionable inherited conditions
- 99% detection rate across ethnicities for the vast majority of the 176 genes on our panel2
MyRisk® Hereditary Cancer Test is a multi-gene panel that helps to determine a patient’s risk by evaluating a number of hereditary cancer syndromes, with focus on 11 primary cancer sites.
- All-in-one personalized cancer risk assessment
- Evaluates 48 genes associated with 11 different hereditary cancers
- RiskScore® predicts a patient’s 5-year and lifetime risk of developing breast cancer
Prequel resources
References:
- Hancock S, Ben-Shachar R, Adusei C, et al. Clinical experience across the fetal-fraction spectrum of a non-invasive prenatal screening approach with low test-failure rate. Ultrasound Obstet Gynecol. 2020;56(3):422-430. doi:10.1002/uog.21904.
- Muzzey D, Goldberg JD, Haverty C. Noninvasive prenatal screening for patients with high body mass index: Evaluating the impact of a customized whole genome sequencing workflow on sensitivity and residual risk. Prenat Diagn. 2020;40(3):333-341. doi:10.1002/pd.5603.
- Welker et al. High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening. Genet Med 23, 443–450 (2021).
- Hammer C, Pierson S, Acevedo A, Goldberg J, Westover T, Chawla D, Mabey B, Muzzey D, Johansen Taber K. High positive predictive value 22q11.2 microdeletion screening by prenatal cell-free DNA testing that incorporates fetal fraction amplification. Prenat Diagn. Epub 2024. doi: 10.1002/pd.6562
